Abstract
Potent 5-HT(2A) inverse-agonists containing phenyl-pyrazole ureas with an amino side chain were identified. Optimization of this series resulted in selective compounds that proved effective in modulating 5HT-induced amplification of ADP-stimulated human platelet aggregation.
MeSH terms
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Humans
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Platelet Aggregation / drug effects
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Platelet Aggregation Inhibitors / chemistry*
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Platelet Aggregation Inhibitors / pharmacology*
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Pyrazoles / chemistry
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Pyrazoles / pharmacology
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Receptor, Serotonin, 5-HT2A / metabolism
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Serotonin 5-HT2 Receptor Agonists*
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Structure-Activity Relationship
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Urea / analogs & derivatives*
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Urea / pharmacology*
Substances
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Platelet Aggregation Inhibitors
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Pyrazoles
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Receptor, Serotonin, 5-HT2A
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Serotonin 5-HT2 Receptor Agonists
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pyrazole
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Urea